Aim: the idea behind the study project comes from research carried out on materials in the aesthetic field for facial scrubbing, that penetrate the skin pores to eliminate impurities. The goal is to create an irrigation root canal gel based on HA, SiO2 and biguanide agents, capable of drastically reducing the microbial load while simultaneously improving the performance of the mechanical reaming, in respect of the biological tissues and the organism.
Methods: significant differences among groups were assessed through two-way ANOVA by using GraphPad Prism 8.0, and the comparisons between the means were calculated by the student t-test. The data are expressed as means ± standard deviation (SD) of three independent experiments.
Results:
- The Alamar Blue test shows that the gel is well tolerated by
the cells, after 6 hours of application, the vitro cell viability is still
77%. - Bacterial growth is totally inhibited in liquid soil, in fact the addition of E. faecalis does not cause any increase in O.D. (which
instead for E. faecalis alone are higher). - The plate activity shows a 1 cm halo of bacterial growth inhibition.
Conclusions: the gel has a thixotropic effect, chemical stability, cleaning and lubricating action, simplified penetration andbiocompatibility. It can be used in combination with physiological solution, as an alternative to sodium hyplochlorite and EDTA.
D’Ambrosio A.P. et al. (2022). DEVELOPMENT OF NEW MATERIALS FOR ROOT CANAL IRRIGATIONIN ENDODONTICS: “ENDOGEL”. Published in Dental Cadmos.
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